Diabetes-induced changes in cardiac voltage-gated ion channels

Diabetes mellitus affects the heart through various mechanisms such as microvascular defects, metabolic abnormalities, autonomic dysfunction and incompatible immune response. Furthermore, it can also cause functional structural changes in myocardium by a disease known diabetic cardiomyopathy (DCM) absence of coronary artery disease. As DCM progresses causes electrical remodeling heart, left ventricular failure. Electrophysiological contribute significantly to incidence arrhythmias sudden cardiac death diabetes patients. In recent studies, significant repolarizing K+ currents, Na+ currents L-type Ca2+ along with impaired homeostasis defective contractile function have been identified heart. addition, insulin levels other trophic factors change maintain ionic channel expression There are many diagnostic tools management options for DCM, but is difficult detect its development effectively prevent progress. this review, diabetes-associated alterations voltage-sensitive ion channels comprehensively assessed understand their potential role pathophysiology pathogenesis DCM.